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  • Tag Archive for "Hypoxic Microenvironments" -
    and HypOxygen our US distributor partnered with Cell Press to sponsor a research based nucleus focusing on cells in low oxygen The Cell Press webinar on Hypoxic Microenvironments was a great opportunity to hear Randall Johnson of the Karolinska Institute speak about the hypoxia response in the context of metastasis and Hannele Ruohola Baker of the University of Washington talk about the role of hypoxia factors in the reprogramming of somatic cells We believe our commitment to providing the most reliable precise and robust equipment for physiological cell culture helps our users to carry out their research and we are happy to be a small part of that Whitley Hypoxystations create an in vivo environment for cell culture and manipulation for the duration of the incubation including functional studies at low oxygen If you want to check back into the webinar the on demand version is available here The Cell Press nucleus comprising selected papers on cancer inflammation stem cells and neural development offers valuable insights into hypoxia as it relates to function and disease too Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June

    Original URL path: http://www.dwscientific.co.uk/blog/tag/hypoxic-microenvironments/ (2016-02-11)
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  • Tag Archive for "HypOxygen" -
    lab recently presented her results obtained in the Hypoxystation at the 14th International Wolfsberg Meeting on Molecular Radiation Biology Oncology in Switzerland images shown here Research into the epigenetic regulation of stem cell behavior and fate benefits from a more physiological culture environment as provided by an hypoxia workstation The Hypoxystation by Don Whitley Scientific mimics those physiological conditions in a closed workstation atmosphere tightly controlling oxygen carbon dioxide temperature and humidity for the duration of your cell culture Visit us at the Cell Symposium on Stem Cell Epigenetics in Sitges Spain from September 20 22 to experience the Hypoxystation for yourself Your cells are holding their breath This article was written by Burga Kalz Fuller of HypOxygen Literature on epigenetic regulation of stem cell fate at hypoxia Van den Beucken et al 2014 Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER Nature Communications 5 5203 Tsai and Wu 2014 Epigenetic regulation of hypoxia responsive gene expression focusing on chromatin and DNA modifications Epigenetic regulation Int J Cancer 134 249 256 Lee at al 2015 MicroRNA 26a induced by hypoxia targets HDAC6 in myogenic differentiation of embryonic stem cells Nucl Acids Res 43 4 2057 2073 Ueda et al 2014 The Hypoxia Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth Mol Cell Biol 34 19 3702 3720 Tweet Optimizing oxygen conditions enhances stem cell recovery Posted on July 17th 2015 by Alex Rhodes Categories Australia Case Study Exhibitions Germany News Overseas Exhibitions No Comments Tags hypoxia HypOxygen ISSCR oxygen stem cell Stockholm Two very recent papers published in Cell and Regenerative Medicine have described research into the advantages of reducing the oxygen exposure stem cells experience during isolation and cultivation and the cellular mechanisms involved in translating hypoxia into increased stem cell survival and enhanced transplantation efficacy The data presented by Mantel et al on hematopoietic stem cells and by Kay et al on mesenchymal stem cells caused quite a stir at the recent ISSCR meeting in Stockholm as attendees discussed the implications for their own work Alasdair Kay and co workers at Keele University evaluated the impact of various oxygen glucose and serum levels on culturing human bone marrow derived MSC s They found that the application of more physiological conditions e g 2 oxygen instead of 21 O 2 ambient resulted in significantly increased cell yields the highest yields were achieved in the stringently controlled hypoxic environment of a workstation The authors attribute this to deoxygenation reoxygenation cycles and very brief air exposure for cells cultured in an incubator as compared to the controlled atmosphere in the workstation Transcriptome analysis of hMSC s cultured at 2 incubator vs workstation and 21 oxygen revealed scores of genes that were up or downregulated with very little overlap among the subsets Kay et al have identified downregulation of bone morphogenetic protein BMP2 expression modulation of chemokine C X C motif receptor CXCR2 signaling and LEPR upregulation as causative factors for enhanced hMSC isolation at hypoxia The term extraphysiologic oxygen shock stress EPHOSS for hematopoietic stem cells experiencing hyperoxia outside of their natural niches is introduced by Mantel et al from Indiana University They delineated the detrimental effects of even brief exposure of bone marrow and cord blood to ambient conditions as compared to harvesting and processing HSC s at constant 3 hypoxia Up to 5 fold increased cell numbers and improved engraftment of transplanted HSC s as a result of hypoxic conditions led the authors to question the relevance of the work currently being carried out at ambient oxygen They attribute the beneficial effects of low oxygen on the yield and function of BM and CB stem cells to reduced production of reactive oxygen species ROS implicating the mitochondrial permeability transition pore MPTP cyclophilin CypD and p53 in protection from EPHOSS Mantel et al predict that hypoxic processing will be significant for many other cell types and phenomena such as metabolism of cancer cells and stem cell aging This article was written by Burga Kalz Fuller Product Manager at HypOxygen Alun Kitsell Burga Kalz Fuller and Daniel Secker with a Whitley HI35 Hypoxystation Kay et al BMP2 repression and optimized culture conditions promote human bone marrow derived mesenchymal stem cell isolation 2015 Med 10 2 109 125 Mantel et al Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock 2015 Cell 161 1553 1565 Tweet Hypoxia and stem cells Posted on June 4th 2015 by Deborah Robinson Categories Australia Exhibitions Germany Hypoxystations News Overseas Exhibitions No Comments Tags H35 Hypoxystation hypoxia hypoxia workstation hypoxic workstation HypOxygen Hypoxystation ISSCR Stem Cell Workstation Later this month the international stem cell research community will be travelling to Stockholm for the upcoming International Society for Stem Cell Research ISSCR meeting covering diverse topics from reprogramming and pluripotency of stem cells through tissue engineering and organ regeneration to therapy with stem cells Whitley H135 Hypoxystation Hypoxia is a crucial parameter determining the fate and development of stem cells which leads Don Whitley Scientific to exhibit the Hypoxystation controlled environment workstation for low oxygen cell culture see us on stand no B15 33 Dr Burga Kalz Fuller Product Manager at our American distributor HypOxygen has summarized five recent papers delineating the role of hypoxia in stem cell research Read more Tweet Cell Press Webinar Hypoxic Microenvironments Posted on April 13th 2015 by Deborah Robinson Categories Hypoxystations News Overseas Exhibitions Press Releases No Comments Tags Cell Press hypoxia HypOxygen Hypoxystation The hypoxic microenvironment triggers many of the events underlying cancer progression and stem cell maintenance and or differentiation In maintaining oxygen homeostasis oxygen levels are sensed by mitochondria communicated by reactive oxygen species ROS and conveyed by hypoxia inducible factors HIF s Hypoxia signalling pathways have far reaching consequences for cellular and tissue processes from metabolism through angiogenesis to metastasis Dr Hannele Ruohola Baker University of Washington and Dr Randall Johnson University of Cambridge will be speaking at the upcoming Cell Press webinar on Hypoxic

    Original URL path: http://www.dwscientific.co.uk/blog/tag/hypoxygen/ (2016-02-11)
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  • Visit HypOxygen at the AACR Meeting in San Diego
    The hypoxic microenvironment is a characteristic feature of many solid tumors and the very low level of oxygenation there dramatically influences the Hallmarks of Cancer from reprogramming energy metabolism through sustained angiogenesis to evasion of the immune response And as our Hypoxystation users are showing research into signaling pathways cancer progression and therapy resistance consistently benefits from the use of a closed hypoxia workstation for physiological cell culture The Hypoxystation creates conditions that mimic the cellular microenvironment with regard to oxygen tension temperature and humidity To see what our users are doing in Hypoxia Applications in Cancer Research click here Also Violaine See of the University of Liverpool describes her work using the Hypoxystation in Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non aggressive neighbouring cells published in Oncogenesis 4 2015 which you can find on the DWS website here Ayse Latif University of Manchester has carried out metabolism studies of gynecological cancer cells with the Seahorse XFe Analyzer have a look here HypOxygen hope to see you at the AACR Function of Tumor Microenvironment in Cancer Progression meeting in San Diego between 7 10 January HypOxygen will be showing the Hypoxystation for low oxygen cell culture and would love to tell you more about its benefits If you cant make it to the conference visit HypOxygen online at http www hypoxygen com for US customers or www dwscientific co uk for UK customers Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016

    Original URL path: http://www.dwscientific.co.uk/blog/visit-hypoxygen-at-the-aacr-meeting-in-san-diego/ (2016-02-11)
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  • Tag Archive for "AACR" -
    statement from HypOxygen below expresses this The hypoxic microenvironment is a characteristic feature of many solid tumors and the very low level of oxygenation there dramatically influences the Hallmarks of Cancer from reprogramming energy metabolism through sustained angiogenesis to evasion of the immune response And as our Hypoxystation users are showing research into signaling pathways cancer progression and therapy resistance consistently benefits from the use of a closed hypoxia workstation for physiological cell culture The Hypoxystation creates conditions that mimic the cellular microenvironment with regard to oxygen tension temperature and humidity To see what our users are doing in Hypoxia Applications in Cancer Research click here Also Violaine See of the University of Liverpool describes her work using the Hypoxystation in Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non aggressive neighbouring cells published in Oncogenesis 4 2015 which you can find on the DWS website here Ayse Latif University of Manchester has carried out metabolism studies of gynecological cancer cells with the Seahorse XFe Analyzer have a look here HypOxygen hope to see you at the AACR Function of Tumor Microenvironment in Cancer Progression meeting in San Diego between 7 10 January HypOxygen will be showing the Hypoxystation for low oxygen cell culture and would love to tell you more about its benefits If you cant make it to the conference visit HypOxygen online at http www hypoxygen com for US customers or www dwscientific co uk for UK customers Tweet HypOxygen at AACR Meeting Posted on April 20th 2015 by Deborah Robinson Categories Exhibitions Hypoxystations News Overseas Exhibitions Press Releases No Comments Tags AACR H35 HEPA H35 Hypoxystation i2 Workstation Whitley i2 Instrument Workstation Our American distributors HypOxygen are exhibiting Whitley Workstations at this year s AACR meeting in Philadelphia Go over to their stand to see the i2 Instrument Workstation specifically designed to house a Seahorse XF Analyzer in physiologically relevant conditions H35 Hypoxystation and also to learn about our range of HEPA workstations Pictured here is Evan Kitsell Design Director at Don Whitley Scientific Ltd and Dr Burga Kalz Fuller Product Manager at HypOxygen They will be available to demonstrate the workstations and answer any questions you may have As the AACR s website describes this year s meeting will highlight the latest most exciting discoveries in every area of cancer research and will provide a unique opportunity for investigators from all over the world to meet interact and share their insights This year s meeting theme Bringing Cancer Discoveries to Patients underscores the vital and inextricable link between discovery and treatment and it reinforces the fact that research underpins all the progress we are making in the field toward cancer cures Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus

    Original URL path: http://www.dwscientific.co.uk/blog/tag/aacr/ (2016-02-11)
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  • Tag Archive for "American Association for Cancer Research" -
    this area of work The statement from HypOxygen below expresses this The hypoxic microenvironment is a characteristic feature of many solid tumors and the very low level of oxygenation there dramatically influences the Hallmarks of Cancer from reprogramming energy metabolism through sustained angiogenesis to evasion of the immune response And as our Hypoxystation users are showing research into signaling pathways cancer progression and therapy resistance consistently benefits from the use of a closed hypoxia workstation for physiological cell culture The Hypoxystation creates conditions that mimic the cellular microenvironment with regard to oxygen tension temperature and humidity To see what our users are doing in Hypoxia Applications in Cancer Research click here Also Violaine See of the University of Liverpool describes her work using the Hypoxystation in Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non aggressive neighbouring cells published in Oncogenesis 4 2015 which you can find on the DWS website here Ayse Latif University of Manchester has carried out metabolism studies of gynecological cancer cells with the Seahorse XFe Analyzer have a look here HypOxygen hope to see you at the AACR Function of Tumor Microenvironment in Cancer Progression meeting in San Diego between 7 10 January HypOxygen will be showing the Hypoxystation for low oxygen cell culture and would love to tell you more about its benefits If you cant make it to the conference visit HypOxygen online at http www hypoxygen com for US customers or www dwscientific co uk for UK customers Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus

    Original URL path: http://www.dwscientific.co.uk/blog/tag/american-association-for-cancer-research/ (2016-02-11)
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  • Tag Archive for "San Diego" -
    of work The statement from HypOxygen below expresses this The hypoxic microenvironment is a characteristic feature of many solid tumors and the very low level of oxygenation there dramatically influences the Hallmarks of Cancer from reprogramming energy metabolism through sustained angiogenesis to evasion of the immune response And as our Hypoxystation users are showing research into signaling pathways cancer progression and therapy resistance consistently benefits from the use of a closed hypoxia workstation for physiological cell culture The Hypoxystation creates conditions that mimic the cellular microenvironment with regard to oxygen tension temperature and humidity To see what our users are doing in Hypoxia Applications in Cancer Research click here Also Violaine See of the University of Liverpool describes her work using the Hypoxystation in Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non aggressive neighbouring cells published in Oncogenesis 4 2015 which you can find on the DWS website here Ayse Latif University of Manchester has carried out metabolism studies of gynecological cancer cells with the Seahorse XFe Analyzer have a look here HypOxygen hope to see you at the AACR Function of Tumor Microenvironment in Cancer Progression meeting in San Diego between 7 10 January HypOxygen will be showing the Hypoxystation for low oxygen cell culture and would love to tell you more about its benefits If you cant make it to the conference visit HypOxygen online at http www hypoxygen com for US customers or www dwscientific co uk for UK customers Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen

    Original URL path: http://www.dwscientific.co.uk/blog/tag/san-diego/ (2016-02-11)
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  • Practical and Clinical Microbiology of Anaerobes Course 2016
    for FRCPath Cost 350 VAT 330 VAT for SAM members Cost includes one night accommodation at the Park Plaza Hotel Cardiff and all meals refreshments plus dinner on 9th June Aims of the Course To promote an understanding and awareness of anaerobic bacteria in clinical material To gain an insight into their relevance in clinical microbiology To achieve a basic level of competence in methods used for their isolation and identification To improve the standards of anaerobic microbiology in clinical laboratories Preliminary Programme Thursday 9 June 09 15 09 45 Registration and Coffee 09 45 10 00 Welcome and Introduction 10 00 12 30 Session 1 Back to basics ID susceptibility testing hot topics 12 30 13 30 Lunch 14 00 17 00 Practical Laboratory Session 19 30 for 20 00 Dinner and Quiz Friday 10 June 09 00 12 30 Clinical Case Histories 12 30 13 30 Lunch 14 00 16 00 Practical Laboratory Session 16 00 16 30 Course Review and Departure To reserve your place on the Practical and Clinical Microbiology of Anaerobes 2016 course please contact Deborah Robinson at Don Whitley Scientific Limited on 01274 595728 or Email sales dwscientific co uk Places will be allocated on a first come first served basis Payment accepted by cheque please make payable to Don Whitley Scientific Limited and Visa or Mastercard Sponsored by Don Whitley Scientific Limited Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the

    Original URL path: http://www.dwscientific.co.uk/blog/microbiology-of-anaerobes-course-2016/ (2016-02-11)
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  • Tag Archive for "Anaerobic Bacteriology" -
    wanted a colony counter that combines throughput and automatic colony ID commented Steve Robertson Sales Director The new Protos 3 offers a high performance platform that generates fully traceable data and we know it will be a huge time saving device for microbiologists in food and pharmaceutical laboratories For anyone using a spiral plater for carrying out multiple bacterial enumerations this is a perfect solution Tweet Botulism Cases Rise Posted on February 3rd 2015 by Deborah Robinson Categories Australia Germany News Press Releases No Comments Tags A35 workstation Anaerobic Bacteriology anaerobic chamber Anaerobic Microbiology Anaerobic Workstation Scottish media has recently reported an increase in the number of diagnosed cases of botulism Caused by toxins produced by the bacterium Clostridium botulinum this condition attacks the nervous system can cause paralysis and may be fatal if left untreated There are three types of botulism food borne wound and infant Diagnosis is achieved by conducting tests on samples of blood faeces stomach contents or food to detect the bacteria or toxins Having to send samples off to an external laboratory for analysis can mean delaying diagnosis and by extension treatment for longer than necessary Hospitals which are equipped to perform these tests in house will have a much greater chance of containing and treating this illness effectively Anaerobic jars can be restrictive when processing a large number of samples whereas an anaerobic workstation provides a sustainable environment where parameters can be altered to create the required conditions The Whitley A35 Anaerobic Workstation can accommodate up to 600 x 90mm Petri dishes and like our other anaerobic chambers it provides excellent conditions for the processing incubation and examination of samples without exposure to atmospheric oxygen For more information please contact us Tweet Anaerobes Where to Start Posted on January 23rd 2015 by Deborah Robinson Categories Australia Germany News Press Releases No Comments Tags A35 workstation A45 Workstation A55 Workstation A95 Anaerobic Cabinet Anaerobic Bacteriology anaerobic chamber anaerobic environment anaerobic jars Anaerobic Microbiology Anaerobic Workstation Clinical Microbiology Guide DWS Service Identifying Clinical Anaerobes incubation petri dishes temperature monitoring Whitley A35 Whitley Jar Gassing System WJGS Introduction to Clinical Anaerobic Bacteriology To a newcomer the field of anaerobic research can seem intimidatingly vast With so many varieties of anaerobes and differing means of culturing them you may find yourself wondering whether the method you are using is really the most efficient and cost effective The first thing you need to consider is the type of anaerobe you are cultivating whilst aerotolerant organisms and facultative anaerobes will not be harmed by a small amount of oxygen obligate anaerobes require a completely oxygen free environment We have recently produced a useful reference guide An Introduction to Clinical Anaerobic Bacteriology which enables the reader to isolate and identify 12 commonly occurring and clinically important anaerobic bacteria Read more Tweet New Chilled Incubation Compartment Posted on December 19th 2014 by Deborah Robinson Categories Australia Germany News No Comments Tags A35 workstation A45 Workstation A95 Anaerobic Cabinet Anaerobic Bacteriology anaerobic chamber Anaerobic Microbiology Anaerobic Workstation Whitley A35 If you need to store small quantities of media and samples in anaerobic conditions but at lower than ambient temperatures you can now specify an optional Chilled Incubation Compartment for a Whitley A35 or A45 Workstation This insulated compartment is located on the left hand side of the workstation and is accessed from the main chamber When you open the compartment door the plate carrier basket swings outwards to allow easy access It has a capacity of 10 x 90mm Petri dishes or items of a similar size The temperature in the Chilled Incubation Compartment can be easily adjusted in 0 1 C increments via the workstation s colour touchscreen The operating temperature range is between 12 C and 25 C and the temperature distribution within the compartment is within 2 C This option must be specified at time of order as it is a factory fitted modification Laboratory and main chamber temperatures may influence the upper and lower temperature levels that can be achieved Tweet Did you know How best to clean your workstation Posted on October 29th 2014 by Deborah Robinson Categories Australia Germany Hypoxystations News Press Releases Useful Links No Comments Tags A35 workstation A45 Workstation A55 Workstation A95 Anaerobic Cabinet Anaerobic Bacteriology anaerobic chamber Anaerobic Microbiology Anaerobic Workstation Anotox catalyst Clinical Microbiology Guide DG250 Workstation Don Whitley Don Whitley Scientific DWS Service H35 Hypoxystation H45 Hypoxystation HEPA Workstation hypoxia workstation hypoxic workstation laboratory automation Whitley A35 Whitley A55 Workstation Whitley A95 Workstation This is the 10th in our Did you know series of articles introducing things you may not know about the Whitley range of products and services read on and you may find out something about your workstation that could make your working life easier We regularly receive enquiries from customers with regard to which disinfectants can be safely used inside Whitley Workstations Although it is not practicable to evaluate every available product we have tested the materials compatibility of several sporicidal disinfectants and can now provide comprehensive advice on this topic How often should I clean my workstation DWS recommend that as part of the daily checks users ensure that the workstation is free from spillage and cleaning carried out as necessary Prior to having your workstation serviced however it may be necessary for it to be decontaminated Which disinfectants have DWS tested Spor Klenz peracetic acid approx 0 1 hydrogen peroxide approx 1 0 ready to use product tested without further dilution Chemgene HLD4H quaternary ammonium compounds approx 1 chlorhexidine digluconate approx 1 ready to use product tested without further dilution Safe Hospital hypochlorous acid ready to use product tested without further dilution Tristel Fuse chlorine dioxide approx 1 prepared from concentrated components according to manufacturer s instructions For more information on these tests please see the appendices of your Whitley Workstation user manual Which of the above products are OK for use in a Whitley Workstation Our tests demonstrated that each of these formulations is satisfactory

    Original URL path: http://www.dwscientific.co.uk/blog/tag/anaerobic-bacteriology/ (2016-02-11)
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web-archive-uk.com, 2017-12-11