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  • Working with Whitley Workstations
    the conditions of the incubator become interrupted usually when the incubator door is opened to add or remove samples and equipment When incubators just won t do In a testimonial for Don Whitley Scientific Brad Wouters from Toronto Canada shared this issue An incubator just isn t suitable for that because whenever the door is opened the oxygen concentration changes dramatically and the cells will go through waves of deoxygenation and oxygenation An issue like this could then lead to inaccurate results and potentially jeopardise experiments This is why the Whitley Hypoxystation is ideal for these situations Working in a Whitley Workstation Professor Mann states in his testimonial The design of this workstation has also allowed us to use other essential equipment inside the chamber such as oxygen meters and micromanipulators As opposed to an incubator where samples are placed and perhaps left for days without interaction Whitley Workstations are designed specifically for scientists wanting to carry out tasks inside the workstation Optional features on Whitley Workstations allow them to be tailored perfectly to those who want to conduct experiments in their workstation using additional specialised equipment for example the removable front option Australian testimonial Maintaining an outstanding international reputation Don Whitley Scientific exports its range of products to all corners of the globe In Australia at the Victor Chang Cardiac Research Institute the aim is to reduce the incidence severity and impact of heart diseases and for Dr Dunn and her team precise control of oxygen carbon dioxide temperature and humidity is vital She mentions in her testimonial that with a H35 Hypoxystation she achieves very accurate and reproducible results As well as providing fantastic equipment Don Whitley Scientific ensures that the advice and service we provide to customers is of a high level which is also noticed by Dr Dunn who states Don Whitley Scientific made great efforts to ensure our purchase installation and ongoing use of the machine has been hassle free Dr Dunn with her H35 Hypoxystation Testimonials wanted If you are working with any equipment from Don Whitley Scientific and would like to let us know about your work and your overall experience with our products please don t hesitate to get in touch via our contact form Facebook or Twitter We now feature a variety of customer testimonials on our product pages and these can be accessed through the testimonials tab if we have a testimonial for that product Click here for Brad Wouters testimonial in full Click here for Professor Mann s testimonial in full Click here for Dr Dunn s testimonial in full Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen

    Original URL path: http://www.dwscientific.co.uk/blog/working-with-whitley-workstation/ (2016-02-11)
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  • Don Whitley Scientific exhibit at TCES 2015
    H35 Hypoxystation hypoxic workstation TCES 2015 Tissue Tweet Don Whitley scientific exhibited at TCES 2015 this annual Tissue and Cell Engineering Society event is held at the University Of Southampton between the 19 th 21 st of July TCES 2015 aims to bring together outstanding national and global speakers from stem cell tissue engineering and regenerative medicine industries exploring how our understanding of tissue development and the resulting generation of specifiable tissues can be enhanced through stem cell science and regenerative medicine With special focus on Harnessing and translating interdisciplinary research for cell and tissue engineering the meeting features a programme of workshops and speakers in an effort to justify the excitement expressed from the public and research communities towards the affect ageing and or trauma can have on disease and the loss of tissue Representatives from Don Whitley Scientific are attending the meeting pictured is Daniel Secker exhibiting a Whitley H35 Hypoxystation Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013

    Original URL path: http://www.dwscientific.co.uk/blog/don-whitley-scientific-at-tces-2015/ (2016-02-11)
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  • Tag Archive for "Cell Engineering" -
    Germany Hypoxystations News No Comments Tags Cell Engineering Don Whitley Scientific H35 Hypoxystation hypoxic workstation TCES 2015 Tissue Don Whitley scientific exhibited at TCES 2015 this annual Tissue and Cell Engineering Society event is held at the University Of Southampton between the 19 th 21 st of July TCES 2015 aims to bring together outstanding national and global speakers from stem cell tissue engineering and regenerative medicine industries exploring how our understanding of tissue development and the resulting generation of specifiable tissues can be enhanced through stem cell science and regenerative medicine With special focus on Harnessing and translating interdisciplinary research for cell and tissue engineering the meeting features a programme of workshops and speakers in an effort to justify the excitement expressed from the public and research communities towards the affect ageing and or trauma can have on disease and the loss of tissue Representatives from Don Whitley Scientific are attending the meeting pictured is Daniel Secker exhibiting a Whitley H35 Hypoxystation Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012

    Original URL path: http://www.dwscientific.co.uk/blog/tag/cell-engineering/ (2016-02-11)
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  • Tag Archive for "Tissue" -
    Hypoxystations News No Comments Tags Cell Engineering Don Whitley Scientific H35 Hypoxystation hypoxic workstation TCES 2015 Tissue Don Whitley scientific exhibited at TCES 2015 this annual Tissue and Cell Engineering Society event is held at the University Of Southampton between the 19 th 21 st of July TCES 2015 aims to bring together outstanding national and global speakers from stem cell tissue engineering and regenerative medicine industries exploring how our understanding of tissue development and the resulting generation of specifiable tissues can be enhanced through stem cell science and regenerative medicine With special focus on Harnessing and translating interdisciplinary research for cell and tissue engineering the meeting features a programme of workshops and speakers in an effort to justify the excitement expressed from the public and research communities towards the affect ageing and or trauma can have on disease and the loss of tissue Representatives from Don Whitley Scientific are attending the meeting pictured is Daniel Secker exhibiting a Whitley H35 Hypoxystation Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November

    Original URL path: http://www.dwscientific.co.uk/blog/tag/tissue/ (2016-02-11)
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  • Cancer Conference Targets Metastatic Disease
    8th 2015 by Alex Rhodes Categories Australia Exhibitions Germany Hypoxystations News No Comments Tags Don Whitley Scientific H35 Hypoxystation Tweet Don Whitley Scientific sponsored the 2015 Beatson International Cancer Conference which was held yesterday at the Beatson Institute in Glasgow The meeting entitled Control of Cell Polarity and Movement in Cancer highlighted recent exciting research into the molecular and cellular events that contribute to loss of epithelial polarity during carcinogenesis and how cancer cells acquire different types of polarity that enable them to migrate and invade There was also a focus on the avenues for development of agents to target cells with aberrant polarity and a potential route to treatment of metastatic disease Attending from Don Whitley Scientific were Danny Secker pictured and Steve Robertson who demonstrated a Whitley H35 Hypoxystation to delegates Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 November 2011

    Original URL path: http://www.dwscientific.co.uk/blog/cancer-conference-targets-metastatic-disease/ (2016-02-11)
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  • Stem Cell Research in Stockholm
    are currently convening in Stockholm for the annual meeting of the International Society for Stem Cell Research ISSCR Topics covered in the event range from pluripotency and differentiation through regeneration to disease modelling and tissue engineering All aspects of reprogramming and stem cell maintenance on the one hand and differentiation on the other hand are intricately influenced by the cellular microenvironment Oxygenation is a crucial parameter throughout all these processes both in the natural stem cell niche and during culture in the lab Low oxygen promotes efficient expansion of stem cells in culture while supporting maintenance of the stem cell phenotype Hypoxia can increase the proliferation rate and inhibit senescence of stem cells and promote healing directly and through paracrine effects Therapies utilizing hypoxic cells exhibit improved homing and engraftment to the target tissues as compared to normoxia Hypoxia is a major determinant of many diverse aspects of stem cell biology Don Whitley Scientific will be at the event exhibiting their largest cell culture workstation to date the Whitley H135 Hypoxystation Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013

    Original URL path: http://www.dwscientific.co.uk/blog/stem_cell-research-in-stockholm/ (2016-02-11)
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  • Tag Archive for "Cell Culture Workstation" -
    Cell Workstation Stem cell researchers from all over the world are currently convening in Stockholm for the annual meeting of the International Society for Stem Cell Research ISSCR Topics covered in the event range from pluripotency and differentiation through regeneration to disease modelling and tissue engineering All aspects of reprogramming and stem cell maintenance on the one hand and differentiation on the other hand are intricately influenced by the cellular microenvironment Oxygenation is a crucial parameter throughout all these processes both in the natural stem cell niche and during culture in the lab Low oxygen promotes efficient expansion of stem cells in culture while supporting maintenance of the stem cell phenotype Hypoxia can increase the proliferation rate and inhibit senescence of stem cells and promote healing directly and through paracrine effects Therapies utilizing hypoxic cells exhibit improved homing and engraftment to the target tissues as compared to normoxia Hypoxia is a major determinant of many diverse aspects of stem cell biology Don Whitley Scientific will be at the event exhibiting their largest cell culture workstation to date the Whitley H135 Hypoxystation Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013

    Original URL path: http://www.dwscientific.co.uk/blog/tag/cell-culture-workstation/ (2016-02-11)
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  • Hypoxia and stem cells
    Diverse effects of hypoxia on multiple myeloma MM where a stem cell like population causes relapse are examined Adaptation to hypoxic conditions causes de differentiation decreased proliferation increased tumor initiation ability and complete drug resistance in the MM stem cells These results suggest a strategy of targeting the hypoxic stem cell like population in order to prevent relapse in MM patients 2 CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes Hasegawa et al 2014 Scientific Reports 4 Article number 5228 Establishing high quality iPSC s is critical to the continuing development of stem cell based therapies and Hasegawa et al provide some insight into the mechanisms whereby the hypoxic microenvironment influences stem cell function and differentiation The role of the chemokine c C motif ligand CCL2 in up regulating hypoxia related genes and thus enhancing pluripotency is discussed 3 Hypoxia Inducible Factors Have Distinct and Stage Specific Roles during Reprogramming of Human Cells to Pluripotency Mathieu et al Cell Stem Cell 14 592 605 2014 Hypoxia inducible factors HIF s mediate a shift from oxidative to glycolytic metabolism which is required early in the re programming process of human cells but which is inhibitory in later stages iPSC generation but not hESC renewal is repressed in a late stage specific manner through stabilization of HIF 2α and inhibition of apoptotic caspase 3 Mathieu et al compare cancer with a slow reprogramming process and speculate that the role of hypoxia in achieving pluripotency may have implications for cancer research 4 Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER van den Beucken et al NATURE COMMUNICATIONS 5 5203 2014 Hypoxia promotes stemness in normal tissues and in cancer and van den Beucken at al provide data from breast cancer showing that one parameter effecting this phenotype transition may involve epigenetic suppression of DICER transcription The DICER promoter is silenced at low oxygen tension significantly reducing miRNA processing DICER inhibition stimulates the epithelial mesenchymal transition EMT and promotes the acquisition of a stem cell phenotype all of which drive metastasis in cancer 5 Hypoxic Preconditioning of Mesenchymal Stromal Cells Induces Metabolic changes Enhances Survival and Promotes Cell Retention in vivo Beegle et al Stem Cells 2015 Jun 33 6 1818 28 Mesenchymal stem cells show great promise as therapeutics in regenerative medicine either as direct transplants or through paracrine effects Originating as they do in hypoxic regions of the body such as bone marrow or adipose tissue MSC s subjected to standard high oxygen cell culture at 20 8 tend to show unsatisfactory retention and survival rates after transplantation Beegle et al at the University of Davis Institute for Regenerative Cures show that pre conditioning at 1 oxygen reduces cell death and increases cell numbers of transplanted MSC s in mice They describe a slower glucose metabolism and other mediators of enhanced survival in pre conditioned cells as compared to normoxic controls Leave a Reply Click here to cancel reply You must

    Original URL path: http://www.dwscientific.co.uk/blog/hypoxia-and-stem-cells/ (2016-02-11)
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