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  • Tag Archive for "ISSCR" -
    2 oxygen instead of 21 O 2 ambient resulted in significantly increased cell yields the highest yields were achieved in the stringently controlled hypoxic environment of a workstation The authors attribute this to deoxygenation reoxygenation cycles and very brief air exposure for cells cultured in an incubator as compared to the controlled atmosphere in the workstation Transcriptome analysis of hMSC s cultured at 2 incubator vs workstation and 21 oxygen revealed scores of genes that were up or downregulated with very little overlap among the subsets Kay et al have identified downregulation of bone morphogenetic protein BMP2 expression modulation of chemokine C X C motif receptor CXCR2 signaling and LEPR upregulation as causative factors for enhanced hMSC isolation at hypoxia The term extraphysiologic oxygen shock stress EPHOSS for hematopoietic stem cells experiencing hyperoxia outside of their natural niches is introduced by Mantel et al from Indiana University They delineated the detrimental effects of even brief exposure of bone marrow and cord blood to ambient conditions as compared to harvesting and processing HSC s at constant 3 hypoxia Up to 5 fold increased cell numbers and improved engraftment of transplanted HSC s as a result of hypoxic conditions led the authors to question the relevance of the work currently being carried out at ambient oxygen They attribute the beneficial effects of low oxygen on the yield and function of BM and CB stem cells to reduced production of reactive oxygen species ROS implicating the mitochondrial permeability transition pore MPTP cyclophilin CypD and p53 in protection from EPHOSS Mantel et al predict that hypoxic processing will be significant for many other cell types and phenomena such as metabolism of cancer cells and stem cell aging This article was written by Burga Kalz Fuller Product Manager at HypOxygen Alun Kitsell Burga Kalz Fuller and Daniel Secker with a Whitley HI35 Hypoxystation Kay et al BMP2 repression and optimized culture conditions promote human bone marrow derived mesenchymal stem cell isolation 2015 Med 10 2 109 125 Mantel et al Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock 2015 Cell 161 1553 1565 Tweet Hypoxia and stem cells Posted on June 4th 2015 by Deborah Robinson Categories Australia Exhibitions Germany Hypoxystations News Overseas Exhibitions No Comments Tags H35 Hypoxystation hypoxia hypoxia workstation hypoxic workstation HypOxygen Hypoxystation ISSCR Stem Cell Workstation Later this month the international stem cell research community will be travelling to Stockholm for the upcoming International Society for Stem Cell Research ISSCR meeting covering diverse topics from reprogramming and pluripotency of stem cells through tissue engineering and organ regeneration to therapy with stem cells Whitley H135 Hypoxystation Hypoxia is a crucial parameter determining the fate and development of stem cells which leads Don Whitley Scientific to exhibit the Hypoxystation controlled environment workstation for low oxygen cell culture see us on stand no B15 33 Dr Burga Kalz Fuller Product Manager at our American distributor HypOxygen has summarized five recent papers delineating the role of hypoxia in stem cell research Read more

    Original URL path: http://www.dwscientific.co.uk/blog/tag/isscr/ (2016-02-11)
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  • Hypoxia and Immunity
    on June 14 16 in Sitges Spain As we look forward to the conference Dr Burga Kalz Fuller Product Manager at our American distributor HypOxygen has summarized five interesting and recent papers concerning hypoxia and its role in immunology and cancer research 1 A mechanism of hypoxia mediated escape from adaptive immunity in cancer cells Barsoum et al Cancer Res 2014 Feb 1 74 3 665 74 In cancer cells exposed to hypoxia HIF 1α induced expression of programmed cell death ligand PD L1 which increased the cells resistance to CTL mediated lysis and contributed to tumoral immune escape This effect was blocked through administration of glyceryl trinitrate GTN an agonist of nitric oxide signalling suggesting that NO mimetica inhibiting PD L1 may present a novel cancer therapy strategy 2 HIF mediated innate immune responses cell signaling and therapeutic implications Harris et al Hypoxia 2014 2 47 58 Host defense through innate immune cells takes place in a low oxygen environment where functions as diverse as cytokine secretion and pathogen phagocytosis are modulated by HIF s This review summarises the roles of HIF s in acute and chronic immune response and gives a perspective on therapies targeting the HIF pathway 3 Identification of CD300a as a new hypoxia inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages Raggi et al Innate Immunity October 2014 vol 20 no 7 721 734 Hypoxia is characteristic for sites of inflammation and lesion and monocytes and other immune cells accumulating in these hypoxic areas are specifically stimulated by the low oxygen environment Raggi et al investigated the hypoxic transcriptome and describe members of the CD300 superfamily of immunoregulatory cell surface receptors which are up regulated in hypoxia 4 HIF Transcription Factors Inflammation and Immunity Palazon et al Immunity 41 October 16 2014 Hypoxia signaling pathways which trigger HIF expression act in the immune system to modulate host immune function In this review Palazon et al describe the myriad ways oxygen sensing regulates innate and adaptive immunity 5 Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB Mueller Edenborn Oncotarget April 2015 Mueller Edenborn s group shed light on signalling pathways regulating hypoxia and inflammatory responses which exhibit a surprising degree of cross talk in colon cancer Hypoxia attenuated proinflammatory responses by inhibiting translocation of NF κB into the nucleus demonstrating yet again that both these aspects of the tumour microenvironment influence therapy response Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July

    Original URL path: http://www.dwscientific.co.uk/blog/hypoxia-and-immunity/ (2016-02-11)
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  • Tag Archive for "H35" -
    our American subsidiary HypOxygen were honoured to sponsor this Cell Press webinar and we want to thank Drs Johnson and Ruohola Baker for their excellent talks The Hypoxystation is designed to create hypoxic conditions within a closed temperature and humidity controlled environment and thus enable researchers to culture cells at physiological conditions mimicking the in vivo situation You can now listen to the webinar at your convenience Click here to register for access Words by Dr Burga Kalz Fuller Tweet Hypoxia and Immunity Posted on May 6th 2015 by Deborah Robinson Categories Australia Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases No Comments Tags H35 H35 Hypoxystation hypoxia workstation The upcoming Cell symposium Cancer Inflammation and Immunity will shine a spotlight on research delineating the complex cross talk between inflammatory processes immune response and the development of cancer diseases Don Whitley Scientific will be exhibiting the Whitley H35 Hypoxystation pictured right a controlled environment workstation for low oxygen cell culture at the meeting on June 14 16 in Sitges Spain As we look forward to the conference Dr Burga Kalz Fuller Product Manager at our American distributor HypOxygen has summarized five interesting and recent papers concerning hypoxia and its role in immunology and cancer research 1 A mechanism of hypoxia mediated escape from adaptive immunity in cancer cells Barsoum et al Cancer Res 2014 Feb 1 74 3 665 74 In cancer cells exposed to hypoxia HIF 1α induced expression of programmed cell death ligand PD L1 which increased the cells resistance to CTL mediated lysis and contributed to tumoral immune escape This effect was blocked through administration of glyceryl trinitrate GTN an agonist of nitric oxide signalling suggesting that NO mimetica inhibiting PD L1 may present a novel cancer therapy strategy 2 HIF mediated innate immune responses cell signaling and therapeutic implications Harris et al Hypoxia 2014 2 47 58 Host defense through innate immune cells takes place in a low oxygen environment where functions as diverse as cytokine secretion and pathogen phagocytosis are modulated by HIF s This review summarises the roles of HIF s in acute and chronic immune response and gives a perspective on therapies targeting the HIF pathway 3 Identification of CD300a as a new hypoxia inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages Raggi et al Innate Immunity October 2014 vol 20 no 7 721 734 Hypoxia is characteristic for sites of inflammation and lesion and monocytes and other immune cells accumulating in these hypoxic areas are specifically stimulated by the low oxygen environment Raggi et al investigated the hypoxic transcriptome and describe members of the CD300 superfamily of immunoregulatory cell surface receptors which are up regulated in hypoxia 4 HIF Transcription Factors Inflammation and Immunity Palazon et al Immunity 41 October 16 2014 Hypoxia signaling pathways which trigger HIF expression act in the immune system to modulate host immune function In this review Palazon et al describe the myriad ways oxygen sensing regulates innate and adaptive

    Original URL path: http://www.dwscientific.co.uk/blog/tag/h35/ (2016-02-11)
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  • Free T-Shirt: Hypoxia Research
    1274 595728 sales dwscientific co uk Follow Don Whitley Scientific Free T Shirt Hypoxia Research Posted on April 1st 2015 by Deborah Robinson Categories Hypoxystations News Press Releases No Comments Tags H45 Hypoxystation hypoxia hypoxia workstation hypoxic workstation Tweet Do you culture cells in hypoxic conditions For a limited time only you can earn a free t shirt by taking a few minutes to answer our questions and help us to better fulfil your cell culture needs We want to know what your research focus is how you conduct your cell culture and how you think oxygen content might influence aspects of your cell culture Please click here to complete a very short online form Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 November 2011 October 2011 September 2011 August 2011 April 2011 September 2007 Tag Cloud A35 workstation A45 Workstation A55 Workstation

    Original URL path: http://www.dwscientific.co.uk/blog/free-t-shirt/ (2016-02-11)
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  • Don Whitley Scientific the leading international supplier of microbiology and tissue culture industries | Don Whitley Scientific
    Team Workstation Poster Grant Corporate Literature Practical and Clinical Microbiology of Anaerobes Leeds University Microbiology Prize Posters Refurbished Equipment Secure Login Home Products Products Whitley Anaerobic Workstations Whitley Hypoxic Workstations Whitley HEPA Workstations Whitley Instrument Workstations Whitley Microaerophilic Workstations Spiral Plating Lab Automation Tissue Culture Systems Rapid Methods Sample Preparation Media Preparation Colony Counting Autoclaving Environmental Monitoring Anaerobic Jar System General Laboratory Products Consumables Accessories Service Accreditation Service Accreditation UKAS

    Original URL path: http://www.dwscientific.co.uk/free-tshirt-application/ (2016-02-11)
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  • New: Airlock Tray Storage Racks
    Tray Storage Racks Posted on March 2nd 2015 by Deborah Robinson Categories Anaerobic Australia Germany Hypoxystations News Press Releases No Comments Tags anaerobic station storage rack Anaerobic Workstation hypoxia workstation hypoxystation storage rack Tweet We have produced a new airlock tray storage rack for our Anaerobic and Hypoxic Workstations which can hold up to 4 airlock trays Manufactured from powder coated aluminium these racks are lightweight and durable and a convenient way to organise Petri dishes tissue culture flasks consumables and other small items You don t even need a workstation fitted with a removable front as the rack can be introduced into the chamber through the airlock No excuse for an untidy workspace now For more information please contact us and quote product code A06928 Leave a Reply Click here to cancel reply You must be logged in to post a comment Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 November 2011 October 2011 September 2011 August 2011 April

    Original URL path: http://www.dwscientific.co.uk/blog/new-airlock-tray-storage-racks/ (2016-02-11)
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  • Tag Archive for "anaerobic station storage rack" -
    Follow Don Whitley Scientific Posts Tagged anaerobic station storage rack New Airlock Tray Storage Racks Posted on March 2nd 2015 by Deborah Robinson Categories Anaerobic Australia Germany Hypoxystations News Press Releases No Comments Tags anaerobic station storage rack Anaerobic Workstation hypoxia workstation hypoxystation storage rack We have produced a new airlock tray storage rack for our Anaerobic and Hypoxic Workstations which can hold up to 4 airlock trays Manufactured from powder coated aluminium these racks are lightweight and durable and a convenient way to organise Petri dishes tissue culture flasks consumables and other small items You don t even need a workstation fitted with a removable front as the rack can be introduced into the chamber through the airlock No excuse for an untidy workspace now For more information please contact us and quote product code A06928 Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 November 2011 October 2011 September 2011 August 2011 April 2011 September 2007 Tag Cloud

    Original URL path: http://www.dwscientific.co.uk/blog/tag/anaerobic-station-storage-rack/ (2016-02-11)
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  • Tag Archive for "hypoxystation storage rack" -
    Manufactured from powder coated aluminium these racks are lightweight and durable and a convenient way to organise Petri dishes tissue culture flasks consumables and other small items You don t even need a workstation fitted with a removable front as the rack can be introduced into the chamber through the airlock No excuse for an untidy workspace now For more information please contact us and quote product code A06928 Tweet New Storage Rack Available Posted on December 17th 2014 by Deborah Robinson Categories Australia Germany Hypoxystations News Press Releases No Comments Tags H35 Hypoxystation HEPA Workstation hypoxia workstation hypoxic workstation storage shelves Hypoxystation hypoxystation storage rack tissue culture flask storage Here s a new storage rack that we have designed for use with our Hypoxystation range Manufactured from aluminium and finished in a durable white powder coating this storage facility is comprised of three shelves and can accommodate up to 6 multi well plates twelve T25 tissue culture flasks or a combination of these and other labware Storing your samples in this manner allows the atmosphere to circulate evenly and thereby optimises the conditions for your cells It is also freezer and incubator safe Contact us for more information and quote product code A03780 Tweet Search the Blog Search for Search Categories Anaerobic Australia Case Study Exhibitions Germany Hypoxystations News Overseas Exhibitions Press Releases Useful Links Recent Posts Liverpool Mini Exhibition A crucial update for Dr Rob Fagan at The University of Sheffield Don Whitley Scientific visit Arab Health 2016 Hypoxic Microenvironments Cell Press Nucleus Visit HypOxygen at the AACR Meeting in San Diego Archives February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September

    Original URL path: http://www.dwscientific.co.uk/blog/tag/hypoxystation-storage-rack/ (2016-02-11)
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web-archive-uk.com, 2017-12-13